Scientists often have to work with air-sensitive or hazardous specimens and materials. When developing batteries and in the photovoltaics sector, for instance, materials have to be measured in a vacuum or under an inert gas atmosphere. Physicians, biologists, or nuclear engineers often handle specimens that are so hazardous that they have to be isolated from the environment. To study such specimens and materials with microscopes or spectroscopes, for instance, they have to be placed in the measurement chambers of these analytical devices without getting into contact with the surrounding atmosphere. For this purpose, complex and expensive locks and manipulation devices are required. Researchers of KIT have developed a vacuum box, by means of which the process of bringing in and removing the specimen can be facilitated and the costs are reduced. In a glove box, for instance, the specimen can be put into the vacuum box under an inert gas atmosphere. Then, the closed box can be removed via the lock of the glove box. The vacuum box consists of the specimen plate, a transparent lid, and an opening and closing unit. Under ambient conditions, the lid is pressed by a helical spring against the sealing ring inserted into the base plate, such that the box is closed in an air-tight manner. Outside of the vacuum, the external expansion unit filled with liquid is relieved. If the box is inserted into a vacuum, e.g. into the measurement chamber of an analytical device, the liquid in the expansion unit starts to boil. The expansion unit expands and opens the lid. When the box is removed from the vacuum, the expansion unit slackens and the lid of the vacuum box is closed tightly again by the helical spring. Opening and closing can be repeated any time. By the selection of the liquid in the expansion unit, such as water or alcohol, the pressure and temperature values for opening and closing can be adjusted, such that the shuttle can be used for various applications.