HANNOVER MESSE 2019, 01 - 05 April
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Surmounting the peak with climate zones

Separation process can achieve top performance

Logo Karlsruher Institut für Technologie

Exhibitor

Karlsruher Institut für Technologie

Exhibitor details
Exhibitor details
Logo Surmounting the peak with climate zones

Product description

With some substances, such as antibodies, it is always the case that they naturally occur in the form of mixtures of substances out of which the pure form has to be filtered in a tedious process to make it available for further industries. The aim is to isolate such substances from the mixture in an optimally manner. Adsorption chromatography has proven to be a suitable method to separate liquid mixtures of substances. Here, a so-called fixed-bed column made of glass is filled with a sorption substance to which the target substance is bonded when it flows through the column (sorption). Through modifying the chemical milieu by adding an elution agent, the target substance is separated again (Desorption) and can be extracted in a purified, concentrated form. It has been necessary to use large quantities of chemicals for the washing and elution steps. Scientists at the KIT have developed an advanced separation process to remedy this. While it is based on the conventional chromatography principle, it avoids additional chemicals and achieves significantly better separating performance thanks to thermo-responsive sorption substances in combination with a wandering temperature control zone around the sorption pillar. A chamber with controlled temperature that encloses the column ensures optimum conditions. The dissolved mixture of substances is pumped continuously into the column, and the target substance is bonded to the sorption substance. During this process, a local increase or decrease in temperature is cyclically activated. This climate zone is pushed step by step in the flow direction, although at a speed lower than the flow speed itself. Desorption commences in the climate zone, which results in a concentration peak that leads to an increase in the adsorbed amount of the target substance outside the climate zone. As the zone approaches, this process is repeated, right down to the outlet of the fixed-bed column.

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Hall 2, Stand B16

(Main stand)

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