SBA15 mesoporous silica nanotherapeutics
New active ingredients for successful anti-cancer therapy
SBA-15 is a mesoporous silica with high specific surface (>800 m2/g), which is used in our research upon therapeutics for antitumoral agents. Already used agents like cisplatin and new metal-organic compounds (based on Ti, Sn, Pt, Ru) as well as natural compounds can and were adsorbed into the SBA-15 pores and proofed to be efficacious vs different cancer cell lines. Reduced toxicity was shown in vivo together with heavenly suppressed tumor growth.
Cancer cells ingest the nanoparticles (e.g. endocytosis), which have a size of less than 1μm and the drug can be released at the target site without interacting with blood plasm, proteins etc. and reducing this way side effects, off-target toxicity and preliminary decomposition. For the first time, metal-based drugs showed differentiation to senescent cells upon treatment in our studies and therefore establishing a new way to diminish tumor growth.
The mechanism of action and the pathway of nanoparticles and drugs were studied with fluorescent markers. Thus, drug release and behavior of SBA-15 can be monitored in vitro. Further research is going on to find new leads, which are especially active adsorbed to silica, but less active and less toxic while acting as free drug. The synergetic effects will make this approach safer and biologically more active at the right targets.
Hence, within this project nanoparticles and drug candidates are produced easily and act together to suppress tumors not just by destroying the cell or activating programmed cell death, but stopping the aggressive tumor growth and surpassing resistances.
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